TimmyHTissues that Build Themselves
March 11th 2009 20:09
Specially engineered cells arrange themselves into three-dimensional microtissues.
Cells coated with sticky bits of DNA can self-assemble into functional three-dimensional microstructures. This bottom-up approach to tissue engineering, developed by scientists at Lawrence Berkeley National Laboratory and the University of California, Berkeley, provides a new solution to one of field's biggest problems: the creation of multicellular tissues with defined structures. Unlike top-down methods, in which scientists build cell structures on scaffolds, the new technique allows tissue engineers to dictate the precise geometric interactions of individual cells.
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By Jocelyn Rice
Double trouble: Two clusters have joined together to form a larger, more structurally complex microtissue. By tweaking variables and adding cells in successive iterations, the researchers hope to generate increasingly sophisticated assemblies. Credit: Bertozzi Lab
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By Jocelyn Rice
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